Is a general server error which means it could be anything, however if you check within the error logs for the server you’ll likely find a Fatal Error being thrown when you activate both plugins together.
Or enable WP_DEBUG on your site and then activate both plugins, the actual the server is throwing should be shown on the page rather than just error 500.
If you can post that here we can see what is causing the problem, right now my guess would be your site is running out of memory (in which case you’ll see a ‘Memory exhausted’ error) but that’s just a shot in the dark currently.
Depending on what your current memory limit is set to you may want to increase it anyway, I’d recommend using at least 96MB if you have it available, you may need more depend on your plugins, usage etc.
You can usually update the memory limit using something like:
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